IL-27, a Cytokine, and IFN-λ1, a Type III IFN, Are Coordinated To Regulate Virus Replication through Type I IFN

IL-27, a cytokine, and IFN-λ1, a type III IFN, are coordinated to regulate virus replication through type I IFN.

IL-27, a member of the IL-12 family, plays a critical role in the control of innate and adaptive immune responses. IFN-λ1, a member of the type III IFN family, shows antiviral abilities. In this study, we investigated the effects of IL-27 and IFN-λ1 on the replication of hepatitis B virus (HBV), a major pathogen associated with a high risk for cirrhosis, liver failure, and hepatocellular carcin...

IL-27, a Cytokine, and IFN-l1, a Type III IFN, Are Coordinated To Regulate Virus Replication through Type I IFN

Coordinated To Regulate Virus Replication through Type I IFN

IFN Regulatory Factor Family Members Differentially Regulate the Expression of Type III IFN (IFN- ) Genes

Regulation of IFN-λ1 promoter activity (IFN-λ1/IL-29) in human airway epithelial cells.

The type III (λ) IFNs (IFN-λ1, IFN-λ2, and IFN-λ3) and their receptor are the most recently discovered IFN family. They are induced by viruses and mediate antiviral activity, but type III IFNs have an important, specific functional niche at the immune/epithelial interface, as well as in the regulation of Th2 cytokines. Their expression appears diminished in bronchial epithelial cells of rhinovi...